About sildenafil (Viagra) – NHS

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Viagra is used in adult males to treat ED. The active ingredient in Viagra is sildenafil. (An active ingredient is what makes a drug work.) The drug comes as a tablet that you swallow. Conclusions: In healthy men sildenafil increased sensitivity to nitroglycerin, an exogenous NO donor, approximately 4-fold but did not affect endothelium-dependent, NO-mediated responses in either the hand vein or forearm vasculature. Results suggest a link between sildenafil-induced delayed protection and the activation of a NOS-dependent signaling cascade. Sildenafil-induced protection against necrosis and apoptosis was abolished in myocytes derived from inducible nitric oxide synthase (iNOS), but not from eNOS gene knockout mice. does viagra contain nitric oxide In studies, nitric oxide supplements have lowered blood pressure, similar to several ED medications, such as Viagra (sildenafil). For this reason, taking these medications together might result in excessively low blood pressure. Results suggest a link between sildenafil-induced delayed protection and the activation of a NOS-dependent signaling cascade. Sildenafil-induced protection against Penile erection is a complex process involving psychogenic and hormonal input, and a neurovascular nonadrenergic, noncholinergic mechanism. Nitric oxide (NO) is believed to be the main vasoactive nonadrenergic, noncholinergic neurotransmitter and chemical mediator of penile erection.